In our latest question and answer, the pharmacist discusses even if it is or not hydroxyzine can cause a false-positive for benzodiazepines.

You are watching: Will hydroxyzine show up on a drug test



cindy asked

Will a positive result occur top top a 10 point urine drug test as a benzodiazepine if you room taking hydroxyzine?

At a glance

Hydroxyzine is not known to reason false-positives because that benzodiazepines top top urine medicine tests. However, it has been report to cause false-positives for one more class of drugs, tricyclic antidepressants.



The concern of whether or no a certain drug or supplement can cause a false-positive top top a urine drug screening is a common one and also a great one come ask.

The most frequently utilized tests space urine-based immunoassays, and they room subject to false positives. Studies that advice drugs associated with creating false-positive results regularly provide large lists. Because that example, the complying with have been reported to cause false-positive for opioids alone:

Poppy seeds

Immunoassay urine screenings space subject come false-positive based just on how the tests work:

antibodies are provided to bind to and also react with a stated compound (such as a benzodiazepine). When an antibody finds the link it is looking for and also binds come it; it produces a reaction. Such reactions are taped as a "positive" result.Unfortunately, over there is a difficulty with "cross-reactivity". Drugs that space not gift tested for deserve to occasionally react v the dorn antibody (i.e. "cross-react"), resulting in a "false positive."

As girlfriend are involved with hydroxyzine, let"s take it a watch at that drug and see if the is associated with producing false-positive on medicine tests.

What Is Hydroxyzine?


Hydroxyzine is a sedating first-generation antihistamine, structurally regarded meclizine.

It has actually very similar effects come Benadryl (diphenhydramine), another first-generation antihistamine, however they are technically in different medication classes (hydroxyzine is a "piperazine" antihistamine while Benadryl is an "ethanolamine" antihistamine).

Hydroxyzine HCL Vs. Hydroxyzine Pamoate

Hydroxyzine is available as two various salt forms:

Atarax (hydroxyzine HCl)Vistaril (hydroxyzine pamoate)

There is rather a bit of dispute regarding the different effects every salt type has. The is commonly thought that Atarax is used an ext for itching and also Vistaril is supplied for anxiety and as a sedative.

While a particular individual may have actually slightly various effects with one or the other, many sources, consisting of the prescribing information for both drugs, state they have actually near-identical pharmacokinetic profiles.

The beginning of impact for both is around 15 come 60 minute after acquisition a dose, and both last approximately 4 come 6 hours. Hydroxyzine pamoate may reason slightly more sedation, however.

Does Hydroxyzine reason False Positives for Benzodiazepines On drug Tests?


Benzodiazepines are amongst the most generally prescribed drugs and also are supplied for a wide range of indications, including anxiety disorders, insomnia and also as a muscle relaxant.

Drugs in the benzodiazepine course include:

While useful, benzodiazepines can reason physiologicaldependence and have a danger of abuse and also misuse. Therefore, they are often had in medicine screening tests.

Although there are reports of several drugs causing false-positives because that benzodiazepines on drug tests (e.g., sertraline, oxaprozin),Hydroxyzine has actually not been associated with it. If girlfriend tested positive for a benzodiazepine recently on a urine-based medicine test, hydroxyzine most likely was no the culprit.

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Nevertheless, hydroxyzine has been reported to cause a false hopeful for another class of drugs, tricyclic antidepressants, or TCAs.

One that the most commonly cited studies on urine drug screening, "Urine drug Screening: Practical guide for Clinicians ", states the following about TCA false-positives: