In our recent question and answer, we talk about the safety and security considerations when combining alcohol through fluconazole.

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patty asked

I take it a one day fluconazole dose, 150 mg pill, for a yeast infection. Is that OK to drink alcohol 2 days later? just how long before it leaves your system?


There is no drug interaction in between fluconazole and alcohol, but it generally is not recommended come drink alcohol when recovering from an infection. Alcohol has actually the propensity to decrease immune function, at the very least acutely (1). In addition, it can potentially worsen medication next effects, including:

NauseaDiarrheaUpset stomach

What Is Fluconazole?

Fluconazole, also known through the brand name Diflucan, is a systemic anti-fungal the is generally used for yeast infections and also oral thrush infections. That is generally well tolerated but has been recognized to cause headache, nausea and abdominal muscle pain.

An amazing characteristic the fluconazole is its capacity to eradicate numerous fungal infections, including vaginal fungal infections, in a single dose. This is as result of how fluconazole works and the relatively long fifty percent life the the drug.

How does Fluconazole Work?

Fluconazole works by inhibiting the synthetic of a vital component (ergosterol) the the fungal cabinet membrane. A solitary dose of fluconazole has actually a reported fifty percent life of 30-50 hours(2). In general, a medicine takes around 5 fifty percent lives to be fully metabolized and also eliminated indigenous the body. This essentially way that the medicine is current and active in the body because that 6 to 10 days! that is why a solitary dose is effective for eradicating infections.

After a single dose, symptoms tend to get much better after 1 to 3 days and the bulk of infections room cleared in 7 to 10 days. The clinical cure price with solitary doses of fluconazole is approximately 69%, which is why periodically doctors will recommend acquisition a 2nd dose the fluconazole 7 work after the early stage dose.

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Problems v Alcohol and Fluconazole

In for to acquisition alcohol after ~ fluconazole administration, there is no drug interaction as pointed out above. However, if you room experiencing any type of symptoms indigenous medication usage such as nausea or abdominal muscle pain, alcohol might worsen those next effects. Fluconazole big in the body for a considerable duration of time, 6 to 10 days. If you great to fully avoid alcohol when the drug is present, friend would have to wait that duration of time.