Medically reviewed by Darren Hein, PharmD — created by college of Illinois — updated on September 2, 2018


Mucinex and also Nyquil Cold & Flu space two common, over-the-counter remedies friend can discover on your pharmacist’s shelf. To compare the symptoms that each drug treats and their next effects, interactions, and also warnings to watch if one is a much better option for you.

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The key differences between these drugs are their active ingredients and how those job-related to treat your symptoms.

Mucinex treats chest congestion. The main active ingredient is an expectorant dubbed guaifenesin. It works by thinning the consistency of rubber in your air passages. This i got loose up rubber in your chest for this reason you deserve to cough the up and out.

NyQuil in the interim treats typical cold and flu symptom such together fever, cough, nasal congestion, boy aches and pains, headache, and runny nose and sneezing. The active ingredients are acetaminophen, dextromethorphan, and also doxylamine. This ingredients each work-related a little differently.

For example, paracetamol is a pains reliever and fever reducer. It transforms the method your human body senses pain and regulates temperature. Dextromethorphan suppresses the signal in your brain that trigger your sneeze reflex. Doxylamine, ~ above the other hand, blocks a substance in her body called histamine. This substance reasons allergy symptoms such together itchy, watery eyes, runny nose, and also itchy sleep or throat. Together, this ingredients provide the relief friend can get from NyQuil.

The adhering to table summarizes the differences between Mucinex and NyQuil in ~ a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever, cough, sleep congestion, young aches and pains, headache, ill throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, dental granulesoral liquid capsule, oral solution
Risk the interactionsnoyes
Risk of severe side effectsnoyes

*There is additionally an extra-strength kind of this tablet, which includes twice as lot of the active ingredient.

Forms and also dosage

You have the right to use Mucinex transparent the day, but you generally use NyQuil in ~ night to help you sleep and let her body recover. The ingredient doxylamine in NyQuil also causes drowsiness to assist you get rest.

Mucinex and NyQuil Cold & Flu are just for civilization 12 years and older. However, NyQuil has actually other products that are especially made for children ages 4 come 11 years.

The recommended dosage because that each medicine varies follow to the form. Follow the encourage dosage top top the package of whatever type you choose. You will must ask your physician for the correct dosage that NyQuil to provide to youngsters who room 4 come 11 years old.

Mucinex walk not have the risk of significant side effects. However, the following serious side results may be feasible with NyQuil:

vision problems, such as blurry visiondifficulty urinatingallergic reaction, v symptoms such as:red, skin or blistering skinrashhivesitchingswelling that the face, throat, tongue, lips, eyes, hands, or reduced legsdifficulty breathing or swallowing

If you have actually serious next effects, you should stop utilizing the drug and call her doctor.


Drug interactions can increase or decrease the effect of the other medications. Interaction can additionally increase your danger of side effects. There room no known significant interactions through guaifenesin, the energetic ingredient in Mucinex. However, every three active ingredients that NyQuil communicate with various other drugs.

Acetaminophen can interact with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan can connect with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine can communicate with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such together fentanyl, hydrocodone, methadone, and morphine

You shouldn’t usage Mucinex or NyQuil to treat a permanent cough. Making use of too much can cause harmful effects. You likewise shouldn’t use these products to treat symptom of any medical problem you have actually without talk to your doctor first.

Other conditions

Other problems you may have can affect how NyQuil works for you. In part conditions, this drug have the right to be harmful. Questioning a doctor prior to using NyQuil if friend have:

liver diseaseglaucomaurinating as result of enlarged prostate gland


Don’t usage Mucinex or NyQuil for much longer than seven days. If your symptoms no relieved after a week, contact your doctor and stop using these drugs.

NyQuil has acetaminophen, which have the right to cause significant liver damages if you overuse it. Taking an ext than four doses of NyQuil in 24 hours can cause severe liver damage. Plenty of over-the-counter drugs additionally contain acetaminophen. If you take it NyQuil, make certain you don’t take it with various other drugs that contain acetaminophen. This will help make sure you nothing accidentally use too much of the drug.

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Mucinex and NyQuil room both assets that relieve symptoms the the common cold or flu. The symptom they treat space different. You can take Mucinex and NyQuil with each other safely if you follow the recommended dosage for each drug. However, acquisition Mucinex at night v NyQuil could actually store you native falling asleep. Mucinex will certainly loosen your mucus, which can cause you to wake as much as cough.

Deciding between the two may simply mean selecting the drug that treats the symptom that space bothering girlfriend the most. That course, you must never take any kind of drug if you’re no sure just how to use it or if it’s ideal for you. Constantly talk come your doctor if you have actually questions.